2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140707
    m-PEG-thiol (MW 5000) 99.90%
    m-PEG-thiol (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG-thiol (MW 5000)
  • HY-60263
    (3R)-3-Pyrrolidinemethanol 110013-18-8 99.53%
    (3R)-3-Pyrrolidinemethanol is a molecular building block and the linker of NRX-0492 (HY-153357).
    (3R)-3-Pyrrolidinemethanol
  • HY-130147
    Propargyl-PEG5-OH 1036204-60-0
    Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-OH
  • HY-135049
    Bromo-PEG6-bromide 72713-23-6
    Bromo-PEG6-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bromo-PEG6-bromide
  • HY-140492
    Biotin-PEG8-acid 2143964-62-7 99.81%
    Biotin-PEG8-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG8-acid
  • HY-138466
    Azido-PEG3-C6-Cl 1625717-44-3
    Azido-PEG3-C6-Cl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-C6-Cl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-C6-Cl
  • HY-140470
    Boc-NH-PEG8-CH2CH2COOH 1334169-93-5 99.83%
    Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG8-CH2CH2COOH
  • HY-141287
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid 2183440-74-4 98.07%
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid
  • HY-130504
    Propargyl-PEG1-acid 55683-37-9
    Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM. Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG1-acid
  • HY-140538
    N-Boc-N-bis(PEG2-acid) 2054339-01-2 99.90%
    N-Boc-N-bis(PEG2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Boc-N-bis(PEG2-acid)
  • HY-140196
    Amino-PEG10-Boc 1818294-42-6 99.73%
    Amino-PEG10-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG10-Boc
  • HY-130572
    Azido-PEG5-acid 1425973-16-5 ≥98.0%
    Azido-PEG5-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs, such as the conjugate CPT-APO (CPT: Camptothecin (HY-16560)). Azido-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-acid
  • HY-W044459
    Triethylene glycol monobenzyl ether 55489-58-2 99.25%
    Triethylene glycol monobenzyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Triethylene glycol monobenzyl ether
  • HY-130364
    Fmoc-NH-PEG6-CH2COOH 437655-96-4 ≥98.0%
    Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-NH-PEG6-CH2COOH
  • HY-133229
    Propargyl-PEG4-alcohol 87450-10-0 99.26%
    Propargyl-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG4-alcohol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-alcohol
  • HY-130315
    Br-PEG4-C2-Boc 564476-32-0 ≥98.0%
    Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Br-PEG4-C2-Boc
  • HY-W190728
    Bis-PEG4-TFP ester 1446282-42-3 98.01%
    Bis-PEG4-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG4-TFP ester
  • HY-W045822
    Fmoc-Lys(Pal-Glu-OtBu)-OH 1491158-62-3 99.93%
    Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys(Pal-Glu-OtBu)-OH
  • HY-140932
    Biotin-PEG4-hydrazide 756525-97-0 ≥98.0%
    Biotin-PEG4-hydrazide is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-hydrazide
  • HY-140307A
    Sulfo DBCO-PEG4-Maleimide TEA
    Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Sulfo DBCO-PEG4-Maleimide (TEA) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    Sulfo DBCO-PEG4-Maleimide TEA
PROTAC Linkers Isoform Comparison

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